Binders Syndrome is a very rare disorder affecting the midface (nose and jaw) of a person. It is characterized by hypoplastic development of the midportion of the midfacial skeleton and its associated soft tissue manifestations. The disorder is probably more common than initially believed with only 40 cases described previous to 1980. However, since 1980, 127 cases have been reported. One case of Binder's syndrome treated with onlay split cranial (calvarial) bone grafts is presented. The technique of using split calvarial bone grafts has become increasingly popular in craniofacial surgery and facial trauma reconstruction.

Affected individuals typically have an unusually flat, underdeveloped midface (midfacial hypoplasia), with an abnormally short nose and flat nasal bridge; underdeveloped upper jaw; relatively protruding lower jaw (mandible); and/or a "reverse overbite" (class III malocclusion). In some reported cases, various additional abnormalities have also been present, particularly of the spinal column of the neck (cervical vertebral anomalies). Many researchers suggest that Binder type maxillonasal dysplasia does not represent a distinct disease entity or syndrome, but, rather, is a nonspecific abnormality of the nasomaxillary regions. In most cases, the condition appears to occur randomly for unknown reasons (sporadically); rare familial cases have also been reported.